In-vivo measurement of cortical morphology: means and meanings

Curr Opin Neurol. 2010 Aug;23(4):359-67. doi: 10.1097/WCO.0b013e32833a0afc.


Purpose of review: Study of the variability of the cortical mantle thickness is now a key issue in neuroimaging. Here we describe a more recent trend aiming at the study of the variability of the cortical folding morphology.

Recent findings: Computerized three-dimensional versions of gyrification index and other morphometric features dedicated to the folding patterns are modified in psychiatric syndromes and neurologic disorders. These observations provide new insights into the mechanisms involved in abnormal development or abnormal aging.

Summary: Quantification of the folding morphology will contribute to the global endeavor aiming at building biomarkers from neuroimaging data, with a specific focus on developmental diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Brain Mapping / instrumentation
  • Brain Mapping / methods*
  • Cerebral Cortex / anatomy & histology*
  • Cerebral Cortex / embryology
  • Cerebral Cortex / growth & development
  • Cerebral Cortex / physiology*
  • Computer Simulation / trends*
  • Diagnostic Imaging / instrumentation
  • Diagnostic Imaging / methods*
  • Diagnostic Imaging / trends
  • Humans
  • Image Processing, Computer-Assisted / instrumentation
  • Image Processing, Computer-Assisted / methods*
  • Mental Disorders / pathology
  • Mental Disorders / physiopathology
  • Nervous System Malformations / pathology
  • Nervous System Malformations / physiopathology