Evaluation of the Nano Spray Dryer B-90 for pharmaceutical applications

Pharm Dev Technol. 2011 Aug;16(4):287-94. doi: 10.3109/10837450.2010.485320. Epub 2010 May 21.

Abstract

The vibrating mesh spray technology implemented in the Nano Spray Dryer B-90 was evaluated for pharmaceutical applications by spray drying common pharmaceutical excipients (e.g. trehalose, mannitol) and model drugs (e.g. griseofulvin). Aerosol droplet size measurements investigated the influence of spray solution factors (e.g. viscosity, surface tension) and of vibrating mesh aperture sizes on particle characteristics. Particle deposition on the spray nozzle was addressed by analyzing the influence of spray solute concentration and solvent on the process outcome. Submicron particles with 0.5 ?m and 0.8 ?m mean particle size were obtained at high yields for 50?mg powder amounts.

MeSH terms

  • Aerosols
  • Equipment Design
  • Excipients / chemistry*
  • Griseofulvin
  • Mannitol
  • Microscopy, Electron, Scanning
  • Nanoparticles / ultrastructure*
  • Particle Size*
  • Pharmaceutical Preparations / chemistry
  • Powders
  • Surface Properties
  • Surface Tension
  • Technology, Pharmaceutical / instrumentation*
  • Technology, Pharmaceutical / methods
  • Trehalose

Substances

  • Aerosols
  • Excipients
  • Pharmaceutical Preparations
  • Powders
  • Griseofulvin
  • Mannitol
  • Trehalose