Hormographiella aspergillata: an emerging mould in acute leukaemia patients?

Clin Microbiol Infect. 2011 Feb;17(2):273-7. doi: 10.1111/j.1469-0691.2010.03266.x.


We describe three invasive mould infections due to Hormographiella aspergillata occurring within 1 year in patients undergoing treatment for acute leukaemia. All patients presented with pulmonary infiltrates; one patient additionally had cerebral and ocular involvement. Diagnostic procedures included bronchoalveolar lavage in all, and video-assisted thoracoscopic surgery in two patients. Susceptibility testing was performed by E-test and detected low minimal inhibitory concentrations for voriconazole and amphotericin B. All patients received systemic antifungal therapy; however, all of them died. Despite this cluster of three cases of an unusual mould infection, no hospital source was detected.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Agaricales / isolation & purification*
  • Antifungal Agents / pharmacology
  • Antifungal Agents / therapeutic use
  • Central Nervous System Fungal Infections / microbiology
  • Central Nervous System Fungal Infections / pathology
  • Communicable Diseases, Emerging / epidemiology*
  • Communicable Diseases, Emerging / microbiology
  • Eye Diseases / microbiology
  • Eye Diseases / pathology
  • Fatal Outcome
  • Female
  • Humans
  • Leukemia / complications*
  • Lung Diseases, Fungal / microbiology
  • Lung Diseases, Fungal / pathology
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Mycoses / epidemiology*
  • Mycoses / microbiology


  • Antifungal Agents