Feasibility of liver transient elastography with FibroScan using a new probe for obese patients

Liver Int. 2010 Aug;30(7):1043-8. doi: 10.1111/j.1478-3231.2010.02258.x. Epub 2010 May 14.


Background & aims: Liver stiffness measurement (LSM) failure when using transient elastography occurs in 2-10% of patients, and is generally related to obesity. The aim of this prospective study was to assess the feasibility of LSM when using a new XL probe on patients with a body mass index (BMI) > or =30 kg/m(2).

Methods: For each patient, LSM was performed using both M probe (currently available and dedicated to patients with standard morphology) and XL probe (dedicated to overweighed patients). A blood sample was taken to assess usual biological variables and simple readily available fibrosis blood tests.

Results: Ninety-nine patients were included (27 men, mean age 52 years, mean BMI 40.5 kg/m(2)). LSM was successful (10 valid measurements) in 45% of the cases with the M probe, vs 76% of the cases with the XL probe (P<0.001). Fifty-nine percent of those who could not be measured (<10 valid measurements) using the M probe could successfully be measured using the XL probe. In the 44 patients successfully measured with both probes, LSM was correlated with the platelet count, prothrombin time, gamma-glutamyltransferase, aspartate aminotransferase, fasting glucose, AST platelet ratio index, Forns score and FIB-4.

Conclusion: The new XL probe allows providing a higher rate of LSM than the M probe in patients with an increased BMI and shows promising results for the evaluation of liver fibrosis.

MeSH terms

  • Adult
  • Aged
  • Biomarkers / blood
  • Body Mass Index
  • Elasticity Imaging Techniques / instrumentation*
  • Equipment Design
  • Fatty Liver / blood
  • Fatty Liver / diagnostic imaging*
  • Fatty Liver / etiology
  • Feasibility Studies
  • Female
  • France
  • Humans
  • Liver / diagnostic imaging*
  • Male
  • Middle Aged
  • Obesity / blood
  • Obesity / complications*
  • Obesity / diagnostic imaging
  • Pilot Projects
  • Predictive Value of Tests
  • Prospective Studies


  • Biomarkers