Ultrasound biomicroscopic configurations of the anterior ocular segment in a population-based study the Kumejima Study

Ophthalmology. 2010 Sep;117(9):1720-8, 1728.e1. doi: 10.1016/j.ophtha.2010.01.045. Epub 2010 May 20.

Abstract

Purpose: To characterize quantitatively the configuration of the anterior ocular segment with ultrasound biomicroscopy (UBM) in a population-based setting.

Design: Cross-sectional study.

Participants: Ten percent of 4632 residents aged > or =40 years of Kumejima, an island off southwest Japan, were randomly selected.

Methods: We performed UBM under light and dark conditions in the 4 quadrants of the right eyes. The anatomic landmarks on the anterior ocular segment UBM images were identified by 1 examiner to quantify the peripheral anterior chamber depth (ACD), location of the ciliary body, and iris thickness.

Main outcome measures: Angle-opening distance at 250 and 500 microm from the scleral spur (AOD250, AOD500), trabecular-iris angle (TIA), trabecular-ciliary process distance (TCPD), thickness of the iris (ID), trabecular-anterior iris surface angle (TAIA), trabecular-posterior iris surface angle (TPIA), trabecular-ciliary angle (TCA), and thickness of iris measured at 1000, 2000, and 3000 microm (IT1000, IT2000 and IT3000).

Results: The AOD500 averaged 0.267+/-0.138 (mean +/- standard deviation) and 0.202+/-0.116 mm under light and dark conditions, respectively; TIA 22.2+/-10.0 and 17.0+/-8.9 degrees; TCPD 0.755+/-0.165 and 0.748+/-0.152 mm; and ID 0.412+/-0.053 and 0.457+/-0.062 mm. The peripheral ACD was deepest temporally, then nasally, then inferiorly, and then superiorly (P<0.05, post hoc test). The position of the ciliary body was deepest nasally, then temporally, then inferiorly, and then superiorly (P<0.05). Iris thickness did not differ significantly among the quadrants. Older subjects had a shallower peripheral ACD, more anteriorly located ciliary body, and thinner iris (analysis of covariance, P<0.015). The peripheral ACD was deeper and the ciliary body was located more deeply in men than women (P<0.05), although no intergender differences in iris thickness were seen (P>0.1). Hyperopia, short axial length, and shallow central ACD were significantly correlated with shallower peripheral ACD, anteriorly located ciliary body, and thinner iris (P<0.05). Elevated intraocular pressure was associated with a shallow peripheral ACD (P< or =0.043).

Conclusions: There are significant associations of the peripheral ACD, location of the ciliary body, and iris thickness with age, gender, refractive error, axial length, and intraocular pressure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Anterior Chamber / diagnostic imaging*
  • Ciliary Body / diagnostic imaging*
  • Cross-Sectional Studies
  • Female
  • Glaucoma, Angle-Closure / diagnostic imaging*
  • Humans
  • Hyperopia / diagnosis*
  • Intraocular Pressure*
  • Iris / diagnostic imaging*
  • Japan
  • Male
  • Microscopy, Acoustic
  • Middle Aged
  • Risk Factors
  • Rural Population
  • Sex Factors