Changes in oxygen saturation using two different sedation techniques

Br J Oral Maxillofac Surg. 1991 Apr;29(2):87-9. doi: 10.1016/0266-4356(91)90087-l.


Pulse oximetry was used to assess the degree of hypoxia observed in patients receiving simple midazolam sedation for removal of lower third molars and compared to that seen in patients receiving a combination sedation technique using nalbuphine and midazolam. Results showed that the degree of hypoxia experienced by patients receiving the combination technique was significantly more profound in both incidence and depth than that seen in the group receiving midazolam alone (p less than 0.05).

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Conscious Sedation / adverse effects
  • Conscious Sedation / methods*
  • Drug Combinations
  • Humans
  • Hypoxia / blood
  • Hypoxia / etiology
  • Midazolam / administration & dosage*
  • Midazolam / adverse effects
  • Nalbuphine / administration & dosage*
  • Nalbuphine / adverse effects
  • Oximetry
  • Oxygen / blood
  • Oxygen Consumption* / drug effects


  • Drug Combinations
  • Nalbuphine
  • Midazolam
  • Oxygen