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. 2010 Jun 15;20(12):3764-7.
doi: 10.1016/j.bmcl.2010.04.064. Epub 2010 Apr 19.

New estrogenic compounds isolated from Broussonetia kazinoki

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New estrogenic compounds isolated from Broussonetia kazinoki

Da Yeon Lee et al. Bioorg Med Chem Lett. .

Abstract

Two new and two known compounds were identified as estrogenic constituents from Broussonetia kazinoki. Their structures were elucidated as broussonin A (1), tupichinol C (2), kazinol U (3), and (+)-(2R) kazinol I (4). They showed estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-luciferase reporter genes. They also control the cellular gene expression levels of estrogen-responsive genes. Phytoestrogens from B. kazinoki may have beneficial effects in the treatment of menopausal symptoms.

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