Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 14 (6), 277-90

Large-scale Brain Networks in Cognition: Emerging Methods and Principles


Large-scale Brain Networks in Cognition: Emerging Methods and Principles

Steven L Bressler et al. Trends Cogn Sci.


An understanding of how the human brain produces cognition ultimately depends on knowledge of large-scale brain organization. Although it has long been assumed that cognitive functions are attributable to the isolated operations of single brain areas, we demonstrate that the weight of evidence has now shifted in support of the view that cognition results from the dynamic interactions of distributed brain areas operating in large-scale networks. We review current research on structural and functional brain organization, and argue that the emerging science of large-scale brain networks provides a coherent framework for understanding of cognition. Critically, this framework allows a principled exploration of how cognitive functions emerge from, and are constrained by, core structural and functional networks of the brain.

Similar articles

  • Operational Principles of Neurocognitive Networks
    SL Bressler et al. Int J Psychophysiol 60 (2), 139-48. PMID 16490271. - Review
    Large-scale neural networks are thought to be an essential substrate for the implementation of cognitive function by the brain. If so, then a thorough understanding of co …
  • Organization, Development and Function of Complex Brain Networks
    O Sporns et al. Trends Cogn Sci 8 (9), 418-25. PMID 15350243. - Review
    Recent research has revealed general principles in the structural and functional organization of complex networks which are shared by various natural, social and technolo …
  • Dynamic Functional Connectivity
    AA Ioannides. Curr Opin Neurobiol 17 (2), 161-70. PMID 17379500. - Review
    Recent studies show that anatomical and functional brain networks exhibit similar small-world properties. However, the networks that are compared often differ in what the …
  • [Cognition and Neural Networks, a New Perspective Based on Functional Neuroimaging]
    F Maestú et al. Rev Neurol 37 (10), 962-6. PMID 14634928. - Review
    Executive function, memory or language are more distributed than located in just one area, even the different subprocesses that are included in each of this functions are …
  • Defining Neurocognitive Networks in the BOLD New World of Computed Connectivity
    M Mesulam. Neuron 62 (1), 1-3. PMID 19376059.
    Cognitive functions require the concerted activity of interconnected neuronal clusters that collectively form large-scale networks. In this issue, Seeley and colleagues u …
See all similar articles

Cited by 488 PubMed Central articles

See all "Cited by" articles

Publication types

LinkOut - more resources