Pot1 and telomere maintenance

FEBS Lett. 2010 Sep 10;584(17):3779-84. doi: 10.1016/j.febslet.2010.05.024. Epub 2010 May 21.

Abstract

Proteins that specifically bind the single-stranded overhang at the ends of telomeres have been identified in a wide range of eukaryotes and play pivotal roles in chromosome end protection and telomere length regulation. Here we summarize recent findings regarding the functions of POT1 proteins in vertebrates and discuss the functional evolution of POT1 proteins following gene duplication in protozoa, plants, nematodes and mice.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Fungal Proteins / genetics
  • Gene Duplication
  • Genes, Protozoan
  • Humans
  • Mice
  • Nematoda / genetics
  • Plants / genetics
  • Saccharomyces cerevisiae / genetics
  • Telomerase / genetics
  • Telomerase / metabolism
  • Telomere / genetics
  • Telomere / physiology*
  • Telomere-Binding Proteins / genetics*
  • Yeasts / genetics

Substances

  • Fungal Proteins
  • POT1 protein, human
  • Telomere-Binding Proteins
  • Telomerase