A neuronal migratory pathway crossing from diencephalon to telencephalon populates amygdala nuclei

Fernando García-Moreno; María Pedraza; Luca G Di Giovannantonio; Michela Di Salvio; Laura López-Mascaraque; Antonio Simeone; Juan A De Carlos

doi:10.1038/nn.2556

A neuronal migratory pathway crossing from diencephalon to telencephalon populates amygdala nuclei

Nat Neurosci. 2010 Jun;13(6):680-9. doi: 10.1038/nn.2556. Epub 2010 May 23.

Authors

Fernando García-Moreno¹, María Pedraza, Luca G Di Giovannantonio, Michela Di Salvio, Laura López-Mascaraque, Antonio Simeone, Juan A De Carlos

Affiliation

¹ Instituto Cajal (Consejo Superior de Investigaciones Científicas), Laboratory of Telencephalic Development, Molecular, Cellular and Developmental Neurobiology Department, Madrid, Spain.

PMID: 20495559
DOI: 10.1038/nn.2556

Abstract

Neurons usually migrate and differentiate in one particular encephalic vesicle. We identified a murine population of diencephalic neurons that colonized the telencephalic amygdaloid complex, migrating along a tangential route that crosses a boundary between developing brain vesicles. The diencephalic transcription factor OTP was necessary for this migratory behavior.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amygdala / embryology*
Amygdala / physiology
Animals
Cell Count
Cell Movement / physiology*
Diencephalon / embryology*
Diencephalon / physiology
Electroporation
Homeodomain Proteins / genetics
Homeodomain Proteins / metabolism*
Hypothalamus / embryology
Hypothalamus / physiology
Immunohistochemistry
In Situ Hybridization
In Vitro Techniques
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Nerve Tissue Proteins / genetics
Nerve Tissue Proteins / metabolism*
Neurons / physiology*
RNA Interference
Stem Cell Niche / embryology
Stem Cell Niche / physiology
Telencephalon / embryology*
Telencephalon / physiology

Substances

Homeodomain Proteins
Nerve Tissue Proteins
Otp protein, mouse