Review
doi: 10.1038/nsmb.1842.
Epub 2010 May 23.
Post-translational modifications in signal integration
Affiliations
- PMID: 20495563
- DOI: 10.1038/nsmb.1842
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Review
Post-translational modifications in signal integration
Nat Struct Mol Biol.
2010 Jun.
Abstract
Post-translational modifications of proteins and the domains that recognize these modifications have central roles in creating a highly dynamic relay system that reads and responds to alterations in the cellular microenvironment. Here we review the common principles of post-translational modifications and their importance in signal integration underlying epidermal growth factor receptor signaling and endocytosis, DNA-damage responses and immunity.
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