Post-translational modifications in signal integration

Nat Struct Mol Biol. 2010 Jun;17(6):666-72. doi: 10.1038/nsmb.1842. Epub 2010 May 23.


Post-translational modifications of proteins and the domains that recognize these modifications have central roles in creating a highly dynamic relay system that reads and responds to alterations in the cellular microenvironment. Here we review the common principles of post-translational modifications and their importance in signal integration underlying epidermal growth factor receptor signaling and endocytosis, DNA-damage responses and immunity.

Publication types

  • Review

MeSH terms

  • Animals
  • DNA Damage / physiology
  • Endocytosis / physiology
  • ErbB Receptors / chemistry
  • ErbB Receptors / metabolism
  • Humans
  • Models, Biological
  • Oxygen / metabolism
  • Protein Interaction Domains and Motifs
  • Protein Processing, Post-Translational*
  • Protein Sorting Signals / physiology*
  • Receptors, Tumor Necrosis Factor / chemistry
  • Receptors, Tumor Necrosis Factor / metabolism
  • Signal Transduction / immunology
  • Signal Transduction / physiology*


  • Protein Sorting Signals
  • Receptors, Tumor Necrosis Factor
  • ErbB Receptors
  • Oxygen