Missing pieces in the Parkinson's disease puzzle

Nat Med. 2010 Jun;16(6):653-61. doi: 10.1038/nm.2165. Epub 2010 May 23.


Parkinson's disease is a neurodegenerative process characterized by numerous motor and nonmotor clinical manifestations for which effective, mechanism-based treatments remain elusive. Here we discuss a series of critical issues that we think researchers need to address to stand a better chance of solving the different challenges posed by this pathology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Disease Progression
  • Humans
  • Lewy Bodies / pathology
  • Parkinson Disease / etiology*
  • Parkinson Disease / genetics
  • Parkinson Disease / physiopathology
  • Parkinson Disease / therapy
  • Substantia Nigra / physiopathology