Aseptic meningitis in adult onset Still's disease

Rheumatol Int. 2012 Dec;32(12):4031-4. doi: 10.1007/s00296-010-1529-8. Epub 2010 May 22.


Adult onset Still's disease (AOSD) is a systemic inflammatory disease characterized by high-fevers, articular involvement, maculopapular rash, hepatosplenomegaly, lymphadenopathy, and a neutrophilic leukocytosis. Though systemic complications of AOSD or its treatment are well described in the literature, CNS involvement in AOSD is exceedingly rare and can have protean manifestations. We present a patient with AOSD who developed chronic meningitis and sensorineural hearing loss on treatment, with a review of prior reported cases of aseptic meningitis, to highlight this rare complication of this uncommon illness.

Publication types

  • Case Reports

MeSH terms

  • Hearing Loss, Sensorineural / etiology*
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Male
  • Meningitis, Aseptic / etiology*
  • Methotrexate / therapeutic use
  • Middle Aged
  • Prednisone / therapeutic use
  • Still's Disease, Adult-Onset / complications*
  • Still's Disease, Adult-Onset / drug therapy


  • Immunosuppressive Agents
  • Prednisone
  • Methotrexate