Is fibrinogen the answer to coagulopathy after massive transfusions?

Crit Care. 2010;14(3):154. doi: 10.1186/cc9000. Epub 2010 May 14.


Coagulopathy is a major cause of morbidity and mortality in patients who have suffered severe hemorrhage and received massive transfusions. Administration of a fibrinogen concentrate along with red blood cells can quickly restore hemostasis in a clinically relevant animal model.

Publication types

  • Comment

MeSH terms

  • Disseminated Intravascular Coagulation / drug therapy*
  • Disseminated Intravascular Coagulation / etiology
  • Fibrinogen / pharmacology
  • Fibrinogen / therapeutic use*
  • Hemostasis / drug effects
  • Humans
  • Models, Animal
  • Transfusion Reaction*
  • Treatment Outcome


  • Fibrinogen