Liberation and animation for ventilated ICU patients: the ABCDE bundle for the back-end of critical care

Crit Care. 2010;14(3):157. doi: 10.1186/cc8999. Epub 2010 May 20.


Critically ill patients are frequently prescribed sedatives and analgesics to ensure patient safety, to relieve pain and anxiety, to reduce stress and oxygen consumption, and to prevent patient ventilator dysynchrony. Recent studies have revealed that these medications themselves contribute to worsening clinical outcomes. An evidence-based organizational approach referred to as the ABCDE bundle (Awakening and Breathing Coordination of daily sedation and ventilator removal trials; Choice of sedative or analgesic exposure; Delirium monitoring and management; and Early mobility and Exercise) is presented in this commentary.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Comment

MeSH terms

  • Contraindications
  • Critical Care / methods*
  • Evidence-Based Practice
  • Humans
  • Hypnotics and Sedatives / adverse effects
  • Hypnotics and Sedatives / therapeutic use*
  • Intensive Care Units*
  • Models, Organizational*
  • Respiration, Artificial*


  • Hypnotics and Sedatives