Breath-hold 1H-magnetic resonance spectroscopy for intrahepatic lipid quantification at 3 Tesla

J Comput Assist Tomogr. 2010 May-Jun;34(3):372-6. doi: 10.1097/RCT.0b013e3181cefb89.


Objective: To compare breath-hold 1H-magnetic resonance spectroscopy (1H-MRS) with respiratory-gated 1H-MRS and computed tomography (CT) for quantification of hepatic lipid content.

Methods: Twenty-three premenopausal women underwent breath-hold point-resolved single-voxel 1H-MRS of the liver followed by respiratory-gated 1H-MRS at 3 Tesla and CT slice through the liver. Interscan variability for 1H-MRS was assessed in 6 volunteers. Pearson correlation coefficients, Bland-Altman 95% limit of agreement, and concordance correlation coefficients were calculated.

Results: There was a strong correlation between breath-hold and respiratory-gated 1H-MRS (r = 0.94, P < 0.0001; concordance correlation coefficient, 0.75). Using Bland-Altman analysis, all but 2 data points were within the limits of agreement. Both 1H-MRS techniques had low interscan variability. There was an inverse correlation of both 1H-MRS techniques with CT attenuation values of the liver.

Conclusions: Breath-hold 1H-MRS is a reliable method to measure hepatic lipid content at 3 Tesla. Breath-hold 1H-MRS of the liver provides data that closely correlates with that obtained from longer-duration respiratory-gated technique.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Feasibility Studies
  • Female
  • Humans
  • Lipids / analysis*
  • Liver / chemistry*
  • Magnetic Resonance Spectroscopy / methods*
  • Middle Aged
  • Reproducibility of Results
  • Tomography, X-Ray Computed


  • Lipids