Abstract
Described is the structure-based design and synthesis of a series of tris-triazole G-quadruplex binding ligands utilising the copper catalysed azide-alkyne 'click' reaction. The results of G-quadruplex stabilisation by the ligands are reported and discussed.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Catalysis
-
Copper / chemistry
-
DNA / chemistry
-
Drug Design
-
G-Quadruplexes / drug effects*
-
Humans
-
Ligands
-
Models, Molecular
-
Nucleic Acid Denaturation
-
Spectrometry, Mass, Electrospray Ionization
-
Transition Temperature
-
Triazoles / chemical synthesis
-
Triazoles / chemistry
-
Triazoles / pharmacology
Substances
-
Ligands
-
Triazoles
-
Copper
-
DNA