Molecular epidemiology and brief history of emerging adenovirus 14-associated respiratory disease in the United States

J Infect Dis. 2010 Jul 1;202(1):93-103. doi: 10.1086/653083.


Background: First isolated in the Netherlands in 1955 during an outbreak of acute respiratory disease (ARD) among military recruits, human adenovirus 14 (HAdV-14) has historically been considered rare. With no precedent of circulation in North America, HAdV-14 has been isolated from military and civilian cases of ARD of variable severity since 2003 in the United States.

Methods: Ninety-nine isolates from military and civilian cases from different geographic locations and circulation periods were characterized by restriction enzyme analysis of viral DNA and select gene sequencing.

Results: All examined viruses were found to be identical and to belong to a new genome type designated "HAdV-14p1" (formerly known as "14a"). Comparative alignments of E1A, hexon, and fiber gene sequences with other subspecies B2 HAdVs suggest that HAdV-14p1, like the closely related HAdV-11a, arose from recombination among similar HAdV-11 and HAdV-14 ancestral strains. A deletion of 2 amino acids in the knob region of the fiber protein is the only identified unique characteristic of HAdV-14p1.

Conclusion: The current geographic distribution of HAdV-14p1 involves at least 15 states in the Unites States. The role of the fiber mutations in the recent emergence of HAdV-14p1 ARD in North America warrants further study.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adenoviridae / classification
  • Adenoviridae / genetics*
  • Adenovirus Infections, Human / epidemiology*
  • Adenovirus Infections, Human / virology*
  • Adolescent
  • Adult
  • Aged, 80 and over
  • Child
  • Child, Preschool
  • Communicable Diseases, Emerging
  • Disease Outbreaks
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Middle Aged
  • Military Personnel
  • Molecular Epidemiology
  • Population Surveillance
  • United States
  • Young Adult