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Case Reports
. 2010 Oct;30(5):471-9.
doi: 10.1111/j.1440-1789.2010.01119.x.

The Pathology of Methylmercury Poisoning (Minamata Disease): The 50th Anniversary of Japanese Society of Neuropathology

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Case Reports

The Pathology of Methylmercury Poisoning (Minamata Disease): The 50th Anniversary of Japanese Society of Neuropathology

Komyo Eto et al. Neuropathology. .

Abstract

Methylmercury (Me-Hg) poisoning (Minamata disease: MD) is one of the most severe types of disease caused by humans to humans in Japan. The disease is a special class of food-borne methylmercury intoxication in humans as typified by the outbreak that began in 1953 in Minamata and its vicinity in Kumamoto Prefecture, Japan. There are 450 autopsy cases in Kumamoto and 30 autopsy cases in Niigata Prefecture related to MD in Japan. Two hundred and one cases in Kumamoto and 22 cases in Niigata showed pathological changes of MD. This report provides a brief research history and overview of the pathological changes of MD, and also presents representative cases of adult, infantile and fetal forms of MD among the 450 MD-related autopsy cases in Kumamoto Prefecture.

Keywords: Minamata disease; human autopsy cases; methylmercury poisoning; pathogenesis; three types of Minamata disease.

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