Peroxiredoxin: a central player in immune modulation

Parasite Immunol. 2010 May;32(5):305-13. doi: 10.1111/j.1365-3024.2010.01201.x.

Abstract

Peroxiredoxins (Prx) are a family of anti-oxidants that protect cells from metabolically produced reactive oxygen species (ROS). The presence of these enzymes in the secretomes of many parasitic helminths suggests they provide protection against ROS released by host immune effector cells. However, we recently reported that helminth-secreted Prx also contribute to the development of Th2-responses via a mechanism involving the induction of alternatively activated macrophages. In this review, we discuss the role helminth Prx may play in modulating the immune responses of their hosts.

Publication types

  • Review

MeSH terms

  • Animals
  • Helminth Proteins / immunology*
  • Peroxiredoxins / immunology*

Substances

  • Helminth Proteins
  • Peroxiredoxins