Gestational diabetes insipidus: a review of an underdiagnosed condition

J Obstet Gynaecol Can. 2010 Mar;32(3):225-31. doi: 10.1016/s1701-2163(16)34448-6.


Objective: To review the etiology, diagnosis, and management of diabetes insipidus during pregnancy.

Data sources: A search of the literature was performed in PubMed using key word searching and citation snowballing to identify articles published in English between January 1, 1980, and December 31, 2008, on the subject of diabetes insipidus during pregnancy. Once the articles were identified, a thorough review of all results was conducted. Results and conclusions were compiled and summarized.

Study selection: We reviewed 50 studies selected using the following key words: diabetes insipidus, pregnancy, arginine vasopressin, vasopressinase.

Conclusion: Gestational diabetes insipidus is underdiagnosed because polyuria is often considered normal during pregnancy. Clinicians caring for pregnant women should consider screening for gestational diabetes insipidus, because it could be associated with serious underlying pathology.

Publication types

  • Review

MeSH terms

  • Antidiuretic Agents / therapeutic use
  • Body Water / metabolism
  • Deamino Arginine Vasopressin / therapeutic use
  • Diabetes Insipidus / classification
  • Diabetes Insipidus / diagnosis*
  • Diabetes Insipidus / etiology
  • Diabetes Insipidus / therapy
  • Diabetes, Gestational / classification
  • Diabetes, Gestational / diagnosis*
  • Diabetes, Gestational / etiology
  • Diabetes, Gestational / therapy
  • Diuretics / therapeutic use
  • Female
  • Humans
  • Hydrochlorothiazide / therapeutic use
  • Magnetic Resonance Imaging
  • Pituitary Gland, Posterior / anatomy & histology
  • Pregnancy
  • Puerperal Disorders / diagnosis
  • Puerperal Disorders / etiology
  • Puerperal Disorders / therapy
  • Ultrasonography, Prenatal
  • Vasopressins / metabolism


  • Antidiuretic Agents
  • Diuretics
  • Hydrochlorothiazide
  • Vasopressins
  • Deamino Arginine Vasopressin