[Thymidylate synthase expression and therapeutic effect analysis of pemetrexed in advanced lung adenocarcinoma]

Nan Fang Yi Ke Da Xue Xue Bao. 2010 May;30(5):978-80.
[Article in Chinese]


Objective: To investigate the expression of thymidylate synthase (TS) in patients with advanced lung adenocarcinoma and its relation with the therapeutic effect of pemetrexed.

Methods: The clinicopathological data of 38 patients with stage IIIIB/IV lung adenocarcinoma receiving pemetrexed treatment were retrospectively analyzed. The tumor samples of the patients were collected for detecting TS expression using RT-PCR, and the therapeutic effect of the treatment was analyzed.

Results: TS positivity was found in 26.32 (10/38) of the patients. TS positivity was not correlated to gender, TNM stage or PS score. The total response rate of pemetrexed treatment (CR+PR) was 34.21 (13/38) in these patients, and the rate was 39.29% (11/28) in TS-negative patients, as compared to 20.00% (2/10) in the positive patients (P=0.087). Patients with low TS expression had significantly higher control rate by pemetrexed treatment than those with TS overexpression [89.29% (25/28) vs 40.00% (4/10), P=0.002].

Conclusion: TS expression may serve as a potential indicator of chemosensitivity to pemetrexed in patients with advanced lung adenocarcinoma.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / drug therapy
  • Adenocarcinoma / enzymology
  • Antineoplastic Agents / therapeutic use*
  • Female
  • Folic Acid Antagonists / therapeutic use
  • Glutamates / therapeutic use*
  • Guanine / analogs & derivatives*
  • Guanine / therapeutic use
  • Humans
  • Lung Neoplasms / drug therapy*
  • Lung Neoplasms / enzymology*
  • Male
  • Middle Aged
  • Pemetrexed
  • Retrospective Studies
  • Thymidylate Synthase / metabolism*


  • Antineoplastic Agents
  • Folic Acid Antagonists
  • Glutamates
  • Pemetrexed
  • Guanine
  • Thymidylate Synthase