Science to practice: Can diffusion-weighted MR imaging findings be used as biomarkers to monitor the progression of renal fibrosis?

Radiology. 2010 Jun;255(3):667-8. doi: 10.1148/radiol.100211.


In an experimental murine model of unilateral ureteral obstruction, Togao et al demonstrated that diffusion-weighted (DW) magnetic resonance (MR) imaging can depict and enable monitoring of abnormal changes in the progression of renal fibrosis; because these microstructural changes are complex and multifactorial, future studies focused on their specificity should be performed before they are applied in clinical trials.

Publication types

  • Comment
  • Editorial

MeSH terms

  • Animals
  • Biomarkers
  • Diffusion Magnetic Resonance Imaging*
  • Disease Progression
  • Fibrosis
  • Kidney Diseases / pathology*
  • Mice
  • Ureteral Obstruction / pathology


  • Biomarkers