Necrotising colitis with perforation in diarrhoic patients treated with loperamide

Eur J Clin Pharmacol. 1991;40(4):415-6. doi: 10.1007/BF00265854.


Two cases of necrotising enterocolitis with perforation occurred in patients with paralytic ileus after loperamide therapy. The possible role of loperamide in the pathogenesis of the complications is suggested.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Enterocolitis, Pseudomembranous / chemically induced*
  • Enterocolitis, Pseudomembranous / physiopathology
  • Enterocolitis, Pseudomembranous / surgery
  • Female
  • Humans
  • Intestinal Perforation / physiopathology
  • Intestinal Perforation / surgery*
  • Loperamide / adverse effects*


  • Loperamide