Abstract
Enantioselective Diels-Alder reactions of 1,2-dihydropyridines with acroleins using a novel chiral oxazolidine organocatalyst afforded chiral isoquinuclidines that is an efficient synthetic intermediate of oseltamivir, with fairly good chemical yield and excellent enantioselectivity (90%, up to >99% ee).
MeSH terms
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Antiviral Agents / chemistry*
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Catalysis
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Dihydropyridines / chemistry*
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Oseltamivir / chemistry*
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Oxazoles / chemistry*
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Quinuclidines / chemical synthesis*
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Quinuclidines / chemistry
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Stereoisomerism
Substances
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Antiviral Agents
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Dihydropyridines
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Oxazoles
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Quinuclidines
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oxazolidine
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Oseltamivir