Angiogenesis, lymphangiogenesis, growth pattern, and tumor emboli in inflammatory breast cancer: a review of the current knowledge

Peter B Vermeulen; Kenneth L van Golen; Luc Y Dirix

doi:10.1002/cncr.25169

Angiogenesis, lymphangiogenesis, growth pattern, and tumor emboli in inflammatory breast cancer: a review of the current knowledge

Cancer. 2010 Jun 1;116(11 Suppl):2748-54. doi: 10.1002/cncr.25169.

Authors

Peter B Vermeulen¹, Kenneth L van Golen, Luc Y Dirix

Affiliation

¹ Translational Cancer Research Group and Pathology Department, Cancer Center of the Saint-Augustinus Hospital, University of Antwerp, Wilrijk, Belgium. peter.vermeulen2@telenet.be

PMID: 20503405
DOI: 10.1002/cncr.25169

Abstract

This objective of the current review was to provide the reader with a comprehensive summary of the literature related to 3 important and inter-related features of the biology of inflammatory breast cancer (IBC): angiogenesis, lymphangiogenesis, and the formation of tumor emboli. Information derived from animal models of IBC as well as from translational studies using tissue samples of patients with IBC are discussed.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Angiogenesis Inducing Agents / analysis
Breast Neoplasms / blood supply
Breast Neoplasms / immunology
Breast Neoplasms / pathology*
Female
Humans
Inflammation / pathology*
Lymphangiogenesis*
Mammary Neoplasms, Experimental / pathology
Neoplastic Cells, Circulating / pathology*
Neovascularization, Pathologic*
Vascular Endothelial Growth Factor A / antagonists & inhibitors

Substances

Angiogenesis Inducing Agents
VEGFA protein, human
Vascular Endothelial Growth Factor A