Evidence that Clostridium perfringens theta-toxin induces colloid-osmotic lysis of erythrocytes

Infect Immun. 1991 Jul;59(7):2499-501. doi: 10.1128/iai.59.7.2499-2501.1991.

Abstract

Clostridium perfringens theta-toxin was shown to lyse target erythrocytes by a colloid-osmotic mechanism. Analysis showed the onset of lysis of erythrocytes by theta-toxin could be temporarily stabilized with 0.3 M sucrose. Flow cytometry analysis of the size distribution of theta-toxin-treated erythrocytes showed swelling of the erythrocytes prior to lysis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Bacterial Toxins / pharmacology*
  • Clostridium perfringens / pathogenicity*
  • Colloids
  • Erythrocytes / drug effects*
  • Erythrocytes / ultrastructure
  • Flow Cytometry
  • Hemolysin Proteins
  • Hemolysis*
  • Humans
  • In Vitro Techniques
  • Osmolar Concentration

Substances

  • Bacterial Toxins
  • Colloids
  • Hemolysin Proteins
  • Clostridium perfringens theta-toxin