Abstract
Clostridium perfringens theta-toxin was shown to lyse target erythrocytes by a colloid-osmotic mechanism. Analysis showed the onset of lysis of erythrocytes by theta-toxin could be temporarily stabilized with 0.3 M sucrose. Flow cytometry analysis of the size distribution of theta-toxin-treated erythrocytes showed swelling of the erythrocytes prior to lysis.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Bacterial Toxins / pharmacology*
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Clostridium perfringens / pathogenicity*
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Colloids
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Erythrocytes / drug effects*
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Erythrocytes / ultrastructure
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Flow Cytometry
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Hemolysin Proteins
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Hemolysis*
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Humans
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In Vitro Techniques
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Osmolar Concentration
Substances
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Bacterial Toxins
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Colloids
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Hemolysin Proteins
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Clostridium perfringens theta-toxin