Increased fructose intake as a risk factor for dementia

J Gerontol A Biol Sci Med Sci. 2010 Aug;65(8):809-14. doi: 10.1093/gerona/glq079. Epub 2010 May 26.


The transition in the world age demographic toward older age is associated with an increased risk of neurodegenerative diseases, such as Alzheimer's disease. Risk profiles for dementia may also be changing. Obesity and type 2 diabetes have increased in prevalence in the last half-century and have been associated with increased dementia risk. Specific changes in nutrition may also represent a direct risk. A diet transition in the United States has occurred in the intake of refined sugar, particularly high-fructose corn syrup (HFCS) from a yearly estimate of 8.1 kg/person at the beginning of the XIX century to a current estimate of 65 kg/person. This article considers the association between refined sugar intake, markers of cardiovascular disease risk, and the possible promotion of the development of dementia.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cognition
  • Dementia / etiology*
  • Energy Intake
  • Fructose / adverse effects*
  • Fructose / metabolism
  • Humans
  • Insulin Resistance
  • Metabolic Syndrome / etiology
  • Public Health
  • Risk Factors


  • Fructose