Toxicology mechanism of the persistent organic pollutants (POPs) in fish through AhR pathway

Toxicol Mech Methods. 2010 Jul;20(6):279-86. doi: 10.3109/15376516.2010.485227.


With the development of industry and agriculture, the cases of cancer and tumor have been increasing gradually in the last 30 years, and quite a few cases are caused by persistent organic pollutants (POPs), some of them belonging to environmental endocrine disruptors, and they have become ubiquitous in the environment, especially in the aquatic ecosystem; so this issue has aroused the extensive attention of the world. The mechanism of POPs toxicology is very complicated, but it is mainly mediated by the aryl hydrocarbon receptor (AhR) pathway in fish. In order to gain a comprehensive understanding of the AhR pathway, the present paper focuses on reviewing it from four major steps, including formation of cytosolic complex, translocation of AhR, heterodimerization of AhR, and induction of CYP1A. This study summarized the isoform numbers of AhR pathway genes and the expression patterns in the regulation process of POPs toxicology in zebrafish.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Environmental Monitoring / methods*
  • Environmental Pollutants / analysis
  • Environmental Pollutants / toxicity*
  • Organic Chemicals / analysis
  • Organic Chemicals / toxicity*
  • Protein Transport
  • Receptors, Aryl Hydrocarbon / genetics
  • Receptors, Aryl Hydrocarbon / metabolism*
  • Toxicology / methods*
  • Zebrafish / metabolism


  • Environmental Pollutants
  • Organic Chemicals
  • Receptors, Aryl Hydrocarbon