A double-blind randomized-controlled trial comparing the desensitizing efficacy of a new dentifrice containing carbonate/hydroxyapatite nanocrystals and a sodium fluoride/potassium nitrate dentifrice

J Clin Periodontol. 2010 Jun;37(6):510-7. doi: 10.1111/j.1600-051X.2010.01558.x.

Abstract

Background and aim: Several dentifrices have shown to be effective in reducing dentine hypersensitivity (DH), but more effective products are needed. The aim of the study was to evaluate the desensitizing efficacy of a new dentifrice based on zinc-carbonate hydroxyapatite (CHA) nanocrystals.

Methods and materials: Using a double-blind, randomized design, the new dentifrice was compared with potassium nitrate/fluoride dentifrice (active control). The participant's DH was evaluated at baseline and after 4 and 8 weeks using airblast (primary outcome), tactile, cold water and subjective tests (secondary outcomes).

Results: The final sample consisted of 70 subjects with baseline DH; 36 received the new dentifrice and 34 the control one. Both dentifrices were largely effective; the percentage of score reduction from baseline to 8 weeks was greater than 28% for all tests (and greater than 55% for the cold water test) in both groups. As compared with controls, experimental subjects had a significantly greater improvement in the airblast test score (mean percentage of reduction of 46.0%versus 29.4% in controls) and the subjective test score (47.5%versus 28.1%, respectively), with both differences already being significant after 4 weeks. In contrast, there was no significant difference between groups for either the tactile or cold water tests at any time point and with any outcome.

Conclusions: This study documented that the new dentifrice containing zinc-CHA nanocrystals significantly reduced dentinal hypersensitivity after 4 and 8 weeks, supporting its utility in clinical practice.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Air
  • Apatites / therapeutic use*
  • Biocompatible Materials / therapeutic use*
  • Carbonates / therapeutic use
  • Cold Temperature
  • Dentifrices / therapeutic use*
  • Dentin Desensitizing Agents / therapeutic use*
  • Dentin Sensitivity / classification
  • Dentin Sensitivity / therapy
  • Double-Blind Method
  • Drug Combinations
  • Durapatite / therapeutic use*
  • Female
  • Fluorides / therapeutic use
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Nanoparticles / therapeutic use*
  • Nitrates / therapeutic use*
  • Phosphates / therapeutic use
  • Physical Stimulation
  • Potassium Compounds / therapeutic use*
  • Sodium Fluoride / therapeutic use*
  • Touch
  • Treatment Outcome
  • Water
  • Zinc Compounds / therapeutic use

Substances

  • Apatites
  • Biocompatible Materials
  • Carbonates
  • Dentifrices
  • Dentin Desensitizing Agents
  • Drug Combinations
  • Nitrates
  • Phosphates
  • Potassium Compounds
  • Sensodyne
  • Zinc Compounds
  • Water
  • carboapatite
  • Sodium Fluoride
  • Durapatite
  • zinc carbonate
  • Fluorides
  • potassium nitrate