YLoc--an interpretable web server for predicting subcellular localization

Nucleic Acids Res. 2010 Jul;38(Web Server issue):W497-502. doi: 10.1093/nar/gkq477. Epub 2010 May 27.


Predicting subcellular localization has become a valuable alternative to time-consuming experimental methods. Major drawbacks of many of these predictors is their lack of interpretability and the fact that they do not provide an estimate of the confidence of an individual prediction. We present YLoc, an interpretable web server for predicting subcellular localization. YLoc uses natural language to explain why a prediction was made and which biological property of the protein was mainly responsible for it. In addition, YLoc estimates the reliability of its own predictions. YLoc can, thus, assist in understanding protein localization and in location engineering of proteins. The YLoc web server is available online at www.multiloc.org/YLoc.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Fungal Proteins / analysis
  • Internet
  • Organelles / chemistry
  • Plant Proteins / analysis
  • Proteins / analysis*
  • Reproducibility of Results
  • Sequence Analysis, Protein
  • Software*


  • Fungal Proteins
  • Plant Proteins
  • Proteins