Integrative Structure Modeling of Macromolecular Assemblies From Proteomics Data

Mol Cell Proteomics. 2010 Aug;9(8):1689-702. doi: 10.1074/mcp.R110.000067. Epub 2010 May 27.

Abstract

Proteomics techniques have been used to generate comprehensive lists of protein interactions in a number of species. However, relatively little is known about how these interactions result in functional multiprotein complexes. This gap can be bridged by combining data from proteomics experiments with data from established structure determination techniques. Correspondingly, integrative computational methods are being developed to provide descriptions of protein complexes at varying levels of accuracy and resolution, ranging from complex compositions to detailed atomic structures.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Humans
  • Models, Molecular*
  • Multiprotein Complexes / metabolism*
  • Proteomics / methods*
  • RNA Polymerase II / chemistry
  • RNA Polymerase II / metabolism

Substances

  • Multiprotein Complexes
  • RNA Polymerase II