Antioxidant effect of Triticum aestivium (wheat grass) in high-fat diet-induced oxidative stress in rabbits

Methods Find Exp Clin Pharmacol. 2010 May;32(4):233-5. doi: 10.1358/mf.2010.32.4.1423889.


Wheat grass is used as a general health tonic and is reported to be effective against several medical disorders, although detailed literature is not available. Besides drug therapy, a number of medicinal plants are effective in treating hyperlipidemia. This study examined the effects of wheat grass on high-fat diet-induced hyperlipidemia in rabbits. Thirty rabbits were divided into 3 groups of 10 rabbits each, group I receiving a control diet, group II a high-fat diet and group III a high-fat diet together with wheat grass over a period of 10 weeks. Fasting serum samples from the animals were analyzed for total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), malondialdehyde (MDA), reduced glutathione (GSH) and vitamin C, and the results were compared. The high-fat diet resulted in hyperlipidemia and an increase in oxidative stress, indicated by a significant rise in MDA levels, whereas antioxidant levels of GSH and vitamin C were significantly reduced. Wheat grass supplementation with a high-fat diet resulted in improved lipid levels (decreased total cholesterol and increased HDL-C) together with significantly reduced MDA levels and increased GSH and vitamin C levels. These results indicate the beneficial role of wheat grass in ameliorating hyperlipidemia and the associated oxidative stress.

MeSH terms

  • Animals
  • Antioxidants / pharmacology*
  • Ascorbic Acid / metabolism
  • Dietary Fats / toxicity
  • Female
  • Glutathione / drug effects
  • Glutathione / metabolism
  • Hyperlipidemias / drug therapy*
  • Hyperlipidemias / physiopathology
  • Male
  • Malondialdehyde / metabolism
  • Oxidative Stress / drug effects*
  • Phytotherapy / methods
  • Plant Preparations / pharmacology
  • Rabbits
  • Triticum / chemistry*


  • Antioxidants
  • Dietary Fats
  • Plant Preparations
  • Malondialdehyde
  • Glutathione
  • Ascorbic Acid