Crosstalk between integrin and receptor tyrosine kinase signaling in breast carcinoma progression

BMB Rep. 2010 May;43(5):311-8. doi: 10.5483/bmbrep.2010.43.5.311.


This review explored the mechanism of breast carcinoma progression by focusing on integrins and receptor tyrosine kinases (or growth factor receptors). While the primary role of integrins was previously thought to be solely as mediators of adhesive interactions between cells and extracellular matrices, it is now believed that integrins also regulate signaling pathways that control cancer cell growth, survival, and invasion. A large body of evidence suggests that the cooperation between integrin and receptor tyrosine kinase signaling regulates certain signaling functions that are important for cancer progression. Recent developments on the crosstalk between integrins and receptor tyrosine kinases, and its implication in mammary tumor progression, are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Breast Neoplasms / metabolism*
  • Breast Neoplasms / pathology
  • Disease Progression*
  • Extracellular Matrix / metabolism
  • Female
  • Humans
  • Integrins / metabolism*
  • Neoplasm Metastasis
  • Receptor Protein-Tyrosine Kinases / metabolism*
  • Signal Transduction / physiology*


  • Integrins
  • Receptor Protein-Tyrosine Kinases