P(4-VP) based nanoparticles and composites with dual action as antimicrobial materials

Colloids Surf B Biointerfaces. 2010 Sep 1;79(2):460-6. doi: 10.1016/j.colsurfb.2010.05.013. Epub 2010 May 7.

Abstract

Polymeric 4-VP (p(4-VP)) particles were synthesized in an oil-in-water microemulsion system using various amounts of ethylene glycol dimethacrylate (EGDMA) as crosslinker. The prepared p(4-VP) particles were chemically modified to obtain positively charged particles as polyelectrolytes. Furthermore, these p(4-VP) particles were used for in situ Ag and Cu metal nanoparticle syntheses to provide dual action with an additional advantage as bactericidal particles. The synthesized p(4-VP) particles with positive charges and metal constituents were tested for potential antibacterial action against various bacteria such as Staphylococcus aureus ATCC6538, Pseudomonas aeruginosa ATCC9027, Bacillus subtilis ATCC6633, Escherichia coli ATCC8739. It was found that p(4-VP) particles, especially the positively charged forms had potential as antibacterial materials. The synthesized particle dimensions were characterized with TEM, and DLS measurements. Chemical modification of the particles was confirmed by FT-IR spectroscopy and zeta potential measurements, and the metal nanoparticle contents were determined with thermogravimetric (TGA) studies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorption / drug effects
  • Anti-Infective Agents / pharmacology*
  • Bacteria / drug effects
  • Emulsions
  • Methacrylates / chemistry
  • Methacrylates / pharmacology
  • Microbial Sensitivity Tests
  • Nanocomposites / chemistry*
  • Nanocomposites / ultrastructure
  • Nanoparticles / chemistry*
  • Nanoparticles / ultrastructure
  • Particle Size
  • Polymers / pharmacology*
  • Polyvinyls / pharmacology*
  • Spectroscopy, Fourier Transform Infrared

Substances

  • Anti-Infective Agents
  • Emulsions
  • Methacrylates
  • Polymers
  • Polyvinyls
  • poly(4-vinylpyridine)
  • ethylene dimethacrylate