Quantitative genetic interactions reveal biological modularity

Cell. 2010 May 28;141(5):739-45. doi: 10.1016/j.cell.2010.05.019.


Traditionally, research has been reductionist, characterizing the individual components of biological systems. But new technologies have increased the size and scope of biological data, and systems approaches have broadened the view of how these components are interconnected. Here, we discuss how quantitative mapping of genetic interactions enhances our view of biological systems, allowing their deeper interrogation across different biological scales.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino-Acid N-Acetyltransferase
  • Animals
  • Epistasis, Genetic*
  • Gene Regulatory Networks
  • Humans
  • Systems Biology / methods*


  • Amino-Acid N-Acetyltransferase