Target-selective GABAergic control of entorhinal cortex output

Nat Neurosci. 2010 Jul;13(7):822-4. doi: 10.1038/nn.2570. Epub 2010 May 30.

Abstract

The medial entorhinal cortex (MEC) is a major center for spatial navigation and memory. We found that cannabinoid type 1 receptor-expressing GABAergic basket cells selectively innervated principal cells in layer II of the rat MEC that projected outside the hippocampus but avoided neighboring cells that give rise to the perforant pathway to the dentate gyrus. These results indicate that the organization of GABAergic microcircuits reflects the long-distance axonal targets of principal neurons.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calbindins
  • Cell Adhesion Molecules, Neuronal / metabolism
  • Entorhinal Cortex / cytology
  • Entorhinal Cortex / metabolism*
  • Extracellular Matrix Proteins / metabolism
  • Immunohistochemistry
  • Nerve Tissue Proteins / metabolism
  • Neural Inhibition / physiology
  • Neural Pathways / cytology
  • Neural Pathways / metabolism*
  • Neuroanatomical Tract-Tracing Techniques
  • Neurons / classification
  • Neurons / cytology
  • Neurons / metabolism*
  • Rats
  • Receptor, Cannabinoid, CB1 / metabolism*
  • S100 Calcium Binding Protein G / metabolism
  • Serine Endopeptidases / metabolism
  • gamma-Aminobutyric Acid / metabolism*

Substances

  • Calbindins
  • Cell Adhesion Molecules, Neuronal
  • Extracellular Matrix Proteins
  • Nerve Tissue Proteins
  • Receptor, Cannabinoid, CB1
  • S100 Calcium Binding Protein G
  • gamma-Aminobutyric Acid
  • Serine Endopeptidases
  • reelin protein