Chromium attenuates high-fat diet-induced nonalcoholic fatty liver disease in KK/HlJ mice

Biochem Biophys Res Commun. 2010 Jul 2;397(3):459-64. doi: 10.1016/j.bbrc.2010.05.129. Epub 2010 May 27.


Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease associated with insulin resistance, oxidative stress, and inflammation. Evidence indicates that chromium has a role in the regulation of glucose and lipid metabolism and may improve insulin sensitivity. In this study, we report that chromium supplementation has a beneficial effect against NAFLD. We found that KK/HlJ mice developed obesity and progressed to NAFLD after feeding with high-fat diet for 8weeks. High-fat-fed KK/HlJ mice showed hepatocyte injury and hepatic triglyceride accumulation, which was accompanied by insulin resistance, oxidative stress, and inflammation. Chromium supplementation prevented progression of NAFLD and the beneficial effects were accompanied by reduction of hepatic triglyceride accumulation, elevation of hepatic lipid catabolic enzyme, improvement of glucose and lipid metabolism, suppression of inflammation as well as resolution of oxidative stress, probably through enhancement of insulin signaling. Our findings suggest that chromium could serve as a hepatoprotective agent against NAFLD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromium / administration & dosage*
  • Diet
  • Dietary Fats / adverse effects*
  • Dietary Supplements*
  • Fatty Liver / etiology
  • Fatty Liver / pathology
  • Fatty Liver / prevention & control*
  • Hypercholesterolemia / prevention & control
  • Insulin Resistance
  • Male
  • Mice
  • Mice, Inbred Strains
  • Oxidative Stress / drug effects
  • Weight Gain / drug effects


  • Dietary Fats
  • Chromium