Osteosarcoma: improvement in survival limited to high-grade patients only

J Cancer Res Clin Oncol. 2011 Apr;137(4):597-607. doi: 10.1007/s00432-010-0923-7. Epub 2010 Jun 1.


Background: We sought to identify the significant prognostic parameters of patients with osteosarcoma over the past three decades using a population-based registry.

Methods: A total of 3765 patients with osteosarcoma were identified in the SEER database. Information regarding patient demographics, clinical and treatment characteristics, cause of death and survival were extracted. Kaplan-Meier, Log-Rank, and Cox regression were used for analysis.

Results: On multivariate analysis only age group '<25 years', 'local' stage and 'low' grade, 'appendicular skeleton' and employment of 'surgical resection' showed a disease-specific survival benefit with a P value < 0.001. The long-term survival improved in the interval from 1973 to 1985 from approximately 55 to 65% but subsequent improvement has been limited only to patients with high-grade disease.

Conclusion: When comparing survival rates by decade of diagnosis, it appears that improvement in survival since 1985 is limited to patients with high-grade disease only.

Level of evidence: The level of evidence for this article is 2.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Bone Neoplasms / mortality*
  • Bone Neoplasms / pathology
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Middle Aged
  • Osteosarcoma / mortality*
  • Osteosarcoma / pathology
  • SEER Program