Protective role of salidroside against aging in a mouse model induced by D-galactose

Biomed Environ Sci. 2010 Apr;23(2):161-6. doi: 10.1016/s0895-3988(10)60047-5.


Objective: To investigate the protective effects of putative AGEs (advanced glycation endproducts) inhibitor salidroside against aging in an accelerated mouse aging model induced by D-galactose.

Methods: A group of 5-month-old C57BL/6J mice were treated daily with D-galactose, D-galactose combined with salidroside, salidroside alone, and control buffer for 8 weeks. At the end of the treatment, serum AGEs levels, neurological activities, expression of glial fibrillary acidic protein (GFAP) and neurotrophin-3 (NT-3) in the cerebral cortex, as well as lymphocyte proliferation and IL-2 production were determined.

Results: D-galactose induced mouse aging model was developed as described before. As expected, salidroside blocked D-galactose induced increase of serum AGEs levels. It also reversed D-galactose induced aging effects in neural and immune system, as evidenced by improving motor activity, increasing memory latency time, and enhancing lymphocyte mitogenesis and interleukin-2 (IL-2) production. Furthermore, elevated expression of GFAP and NT-3 in the aged model mice was also reduced upon salidroside treatment.

Conclusion: Salidroside inhibits AGEs formation in vivo, which at least partially contributes to its anti-aging effect in D-galactose induced aging model.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging, Premature / blood
  • Aging, Premature / chemically induced
  • Aging, Premature / prevention & control*
  • Animals
  • Cerebral Cortex / metabolism
  • Drugs, Chinese Herbal / pharmacology
  • Drugs, Chinese Herbal / therapeutic use*
  • Galactose
  • Glial Fibrillary Acidic Protein
  • Glucosides / pharmacology
  • Glucosides / therapeutic use*
  • Glycation End Products, Advanced / blood
  • Interleukin-2 / metabolism
  • Memory / drug effects
  • Mice
  • Mice, Inbred C57BL
  • Motor Activity / drug effects
  • Nerve Growth Factors / metabolism
  • Nerve Tissue Proteins / metabolism
  • Phenols / pharmacology
  • Phenols / therapeutic use*
  • Spleen / drug effects
  • Spleen / immunology
  • T-Lymphocytes / drug effects


  • Drugs, Chinese Herbal
  • Glial Fibrillary Acidic Protein
  • Glucosides
  • Glycation End Products, Advanced
  • Interleukin-2
  • Nerve Growth Factors
  • Nerve Tissue Proteins
  • Phenols
  • glial fibrillary astrocytic protein, mouse
  • neurotropin 3, mouse
  • rhodioloside
  • Galactose