Replication Protein A: Directing Traffic at the Intersection of Replication and Repair

Front Biosci (Landmark Ed). 2010 Jun 1;15:883-900. doi: 10.2741/3652.


Since the initial discovery of replication protein A (RPA) as a DNA replication factor, much progress has been made on elucidating critical roles for RPA in other DNA metabolic pathways. RPA has been shown to be required for DNA replication, DNA repair, DNA recombination, and the DNA damage response pathway with roles in checkpoint activation. This review summarizes the current understanding of RPA structure, phosphorylation and protein-protein interactions in mediating these DNA metabolic processes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DNA Damage
  • DNA Repair*
  • DNA Replication*
  • DNA, Single-Stranded / genetics
  • DNA, Single-Stranded / metabolism*
  • Humans
  • Protein Binding
  • Recombination, Genetic
  • Replication Protein A / metabolism*


  • DNA, Single-Stranded
  • Replication Protein A