TRPC channels in smooth muscle cells

Front Biosci (Landmark Ed). 2010 Jun 1;15:1023-39. doi: 10.2741/3660.


Transient receptor potential canonical (TRPC) proteins constitute a family of seven (TRPC1-7) nonselective cation channels within the wider TRP superfamily. TRPC1, TRPC3, TRPC4, TRPC5 and TRPC6 channels are expressed in vascular smooth muscle cells from human vessels of all calibers and in smooth muscle from organs such as the uterus and the gastrointestinal tract. TRPC channels have recently emerged as important players in the control of smooth muscle function. This review will focus on the retrospective analysis of studies proposing contributions of TRPC channels to native calcium entry pathways in smooth muscle and to physiological and pathophysiological responses with emphasis on the vascular system.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Calcium / metabolism*
  • Female
  • Gastrointestinal Tract / metabolism
  • Humans
  • Muscle, Smooth, Vascular / cytology
  • Muscle, Smooth, Vascular / metabolism*
  • Protein Isoforms / metabolism
  • Signal Transduction*
  • TRPC Cation Channels / metabolism*
  • Uterus / metabolism
  • Vascular Diseases / metabolism
  • Vascular Diseases / pathology


  • Protein Isoforms
  • TRPC Cation Channels
  • transient receptor potential cation channel, subfamily C, member 1
  • Calcium