Interactions between PrP(c) and other ligands with the 37-kDa/67-kDa laminin receptor

Front Biosci (Landmark Ed). 2010 Jun 1;15:1150-63. doi: 10.2741/3667.

Abstract

The 37-kDa/67 kDa laminin receptor (LRP/LR) represents a multifunctional protein. It is a receptor for viruses such as Dengue viruses, Alphaviruses and Adeno-associated viruses (AAV), as well as the cellular prion protein (PrPc) and infectious prions. Furthermore, the 37-kDa/67-kDa LRP/LR plays fundamental roles in basic cell biological processes such as cell adhesion and cell growth and acts as a key player in metastatic cancer, affecting invasion, adhesion and apoptotic processes. This review gives fundamental insights into basic cellular processes affected by LRP/LR including signal transduction and cell cycle progression and focuses on pathophysiological implications of the interaction of prion proteins, laminin, viruses and other ligands with LRP/LR affecting the development of highly-prevalent diseases such as cancer, neurodegenerative diseases such as prion disorders and Alzheimer's disease as well as viral infections. Molecular tools such as LRP/LR specific antibodies and siRNAs targeting LRP expression as possible alternative therapeutics for the treatment of neurodegenerative diseases, metastatic cancer and viral infections are emphasized.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Physiological Phenomena / genetics
  • Cell Physiological Phenomena / physiology*
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Ligands*
  • Molecular Weight
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Neoplasms / physiopathology
  • PrPC Proteins / metabolism*
  • Protein Binding
  • RNA Interference
  • Receptors, Laminin / chemistry
  • Receptors, Laminin / genetics
  • Receptors, Laminin / metabolism*

Substances

  • Ligands
  • PrPC Proteins
  • Receptors, Laminin