Add-on blockade of (pro)renin receptor in imidapril-treated diabetic SHRsp

Front Biosci (Elite Ed). 2010 Jun 1;2:972-9. doi: 10.2741/e156.

Abstract

To examine the involvement of (pro)renin receptor in the accelerated organ damage in streptozotocin-induced diabetic male SHRsp, the rats fed a high-salt diet were divided into 5 groups: a group treated with the vehicle, a group treated with 15 mg/kg/day of imidapril (ACEi), a group treated with 60 mg/kg/day of imidapril (High ACEi), a group treated with handle region peptide (HRP), and a group treated with both ACEi and HRP (ACEi+HRP). After 8 weeks, the arterial pressure was similar in the vehicle and HRP groups and decreased in the ACEi-treated groups. The renal angiotensin II content decreased similarly in the groups treated with ACEi and/or HRP. Urinary protein excretion also decreased in the ACEi, High ACEi, and HRP groups and significantly further decreased in the ACEi+HRP group. The heart weight of the ACEi+HRP group was significantly lower than that of any other groups, although the cardiac angiotensin II levels decreased similarly in the groups treated with ACEi and/or HRP. Thus, (pro)renin receptor contributes to the accelerated pathogenesis in the heart and kidneys of diabetic SHRsp.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiotensin II / metabolism
  • Animals
  • Blood Glucose
  • Blood Pressure
  • Body Weight
  • Collagen Type I / genetics
  • Diabetes Mellitus, Experimental / drug therapy*
  • Diabetes Mellitus, Experimental / metabolism
  • Diabetes Mellitus, Experimental / physiopathology
  • Imidazolidines / therapeutic use*
  • Male
  • Organ Size
  • RNA, Messenger / genetics
  • Rats
  • Rats, Inbred SHR
  • Receptors, Cell Surface / antagonists & inhibitors*
  • Receptors, Cell Surface / metabolism
  • Reverse Transcriptase Polymerase Chain Reaction
  • Transforming Growth Factor beta / genetics

Substances

  • Blood Glucose
  • Collagen Type I
  • Imidazolidines
  • RNA, Messenger
  • Receptors, Cell Surface
  • Transforming Growth Factor beta
  • prorenin receptor
  • Angiotensin II
  • imidapril