Regulation of T cells in airway disease by beta-agonist

Front Biosci (Schol Ed). 2010 Jun 1;2:969-79. doi: 10.2741/s113.

Abstract

It is widely recognized that Th2 cytokines derived from T cells play a major role in the development of allergic lung inflammation that causes most asthma. Beta-agonists are important rescue and maintenance therapies for asthma, yet our understanding of beta-agonist effects on T cell biology is surprisingly poor. Recent studies using both cell culture and more integrative models are beginning to reveal beta-agonist regulation of T cell signaling and function that may be important in the pathogenesis and treatment of asthma and possibly other inflammatory diseases. Here we provide a comprehensive review of the literature concerning beta-agonist effects on T cells, and discuss the relevance of emerging paradigms of beta-adrenergic receptor signaling to T cell function.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adrenergic beta-Agonists / pharmacology*
  • Animals
  • Asthma / drug therapy*
  • Asthma / etiology
  • Asthma / immunology
  • Asthma / metabolism*
  • Cells, Cultured
  • Cytokines / metabolism
  • Humans
  • Inflammation / immunology
  • Inflammation / metabolism
  • Models, Biological
  • Receptors, Antigen, T-Cell / metabolism
  • Signal Transduction / drug effects
  • T-Lymphocytes / drug effects*
  • T-Lymphocytes / immunology
  • T-Lymphocytes / metabolism*

Substances

  • Adrenergic beta-Agonists
  • Cytokines
  • Receptors, Antigen, T-Cell