Association of longevity with IL-10 -1082 G/A and TNF-alpha-308 G/A polymorphisms

Int J Immunogenet. 2010 Aug;37(4):293-8. doi: 10.1111/j.1744-313X.2010.00925.x. Epub 2010 May 27.

Abstract

Cytokines are crucial for the regulation of inflammation development in humans. Many studies have shown that variations in cytokine genes might play a role in determining human longevity. This study examined the changes in the gene pool relevant to the -308 G/A polymorphism in the promoter region of the proinflammatory cytokine tumour necrosis factor (TNF)-alpha gene and the -1082 G/A polymorphism in the promoter region of anti-inflammatory cytokine interleukin (IL)-10 gene with aging and survival selection occurs in the Jordanian population. IL-10 -1028 G/A and TNF-alpha-308 G/A were genotyped in 119 randomly selected elderly subjects (41 women and 78 men) with a mean age of 90.2 years and young control subjects of 118 (46 women and 72 men) with a mean age of 31.9 years. No significant differences were found in the genotype and allele frequencies of TNF-alpha gene variants between the two groups (P > 0.05) while the IL-10 genotype and allele frequencies were significantly associated with longevity in men (P < 0.05) but not in women (P < 0.05). Thus, IL-10 -1028 G/A polymorphism seems to play a role in the pathway to longevity in Jordanian men.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged, 80 and over
  • Alleles
  • Arabs / genetics*
  • Arabs / statistics & numerical data
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Inflammation / genetics
  • Interleukin-10 / genetics*
  • Interleukin-10 / physiology
  • Jordan / epidemiology
  • Longevity / genetics*
  • Longevity / immunology
  • Male
  • Polymorphism, Restriction Fragment Length
  • Polymorphism, Single Nucleotide*
  • Promoter Regions, Genetic / genetics*
  • Sampling Studies
  • Sex Factors
  • Tumor Necrosis Factor-alpha / genetics*
  • Tumor Necrosis Factor-alpha / physiology

Substances

  • IL10 protein, human
  • Tumor Necrosis Factor-alpha
  • Interleukin-10