Abstract
Summary Here, we describe the characterisation of a new allelic variant of HLA-B*57. The novel allele, HLA-B*5728N, was identified with sequence-based typing in a Caucasoid family. HLA-B*5728N, differs from HLA-B*5701 because of a nucleotide substitution at position 420 (C->G) resulting in a coding change from Tyrosine to a stop codon.
MeSH terms
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Alleles
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Amino Acid Substitution
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Base Sequence
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Codon, Terminator
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Exons / genetics
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Female
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Genes, MHC Class I*
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HLA-B Antigens / genetics*
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Haplotypes / genetics
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Histocompatibility Testing / methods*
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Humans
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Immunoblotting
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Male
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Molecular Sequence Data
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Polymerase Chain Reaction
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Sequence Alignment
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Sequence Analysis, DNA
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Sequence Homology, Nucleic Acid
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Serologic Tests
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White People / genetics
Substances
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Codon, Terminator
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HLA-B Antigens
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HLA-B57 antigen