R spider: a network-based analysis of gene lists by combining signaling and metabolic pathways from Reactome and KEGG databases

Nucleic Acids Res. 2010 Jul;38(Web Server issue):W78-83. doi: 10.1093/nar/gkq482. Epub 2010 Jun 2.

Abstract

R spider is a web-based tool for the analysis of a gene list using the systematic knowledge of core pathways and reactions in human biology accumulated in the Reactome and KEGG databases. R spider implements a network-based statistical framework, which provides a global understanding of gene relations in the supplied gene list, and fully exploits the Reactome and KEGG knowledge bases. R spider provides a user-friendly dialog-driven web interface for several model organisms and supports most available gene identifiers. R spider is freely available at http://mips.helmholtz-muenchen.de/proj/rspider.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Computer Graphics
  • Databases, Genetic*
  • Databases, Protein
  • Gene Regulatory Networks*
  • Humans
  • Internet
  • Metabolic Networks and Pathways / genetics*
  • Protein Interaction Mapping*
  • Proteins / genetics
  • Signal Transduction / genetics*
  • Software*
  • Systems Integration
  • User-Computer Interface

Substances

  • Proteins