CSF-1, IGF-1, and the control of postnatal growth and development

J Leukoc Biol. 2010 Sep;88(3):475-81. doi: 10.1189/jlb.0310158. Epub 2010 Jun 2.

Abstract

Growth hormone controls somatic growth in mammals by regulating the production of IGF-1, which is predominantly made by the liver. The development of cells within the MPS is controlled by the lineage-specific growth factor M-CSF (CSF-1). In this review, we summarize the role of CSF-1-dependent macrophages in somatic growth and organogenesis. We propose that macrophages are the major extrahepatic source of IGF-1 and that a surge of CSF-1 production contributes to the control of postnatal growth and organ maturation. Accordingly, CSF-1 may be considered a part of the GH/IGF-1 axis.

Publication types

  • Review

MeSH terms

  • Animals
  • Growth and Development*
  • Humans
  • Insulin-Like Growth Factor I / genetics
  • Insulin-Like Growth Factor I / metabolism*
  • Macrophage Colony-Stimulating Factor / metabolism*
  • Macrophages / metabolism*
  • Receptor, Macrophage Colony-Stimulating Factor / metabolism
  • Transcription, Genetic

Substances

  • Insulin-Like Growth Factor I
  • Macrophage Colony-Stimulating Factor
  • Receptor, Macrophage Colony-Stimulating Factor